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Systemic immunosuppression with mycophenolate mofetil to prevent corneal graft rejection after high risk penetrating keratoplasty: a 2‐year follow‐up study
Author(s) -
Szaflik J.P.,
Major J.,
Izdebska J.,
Lao M.,
Szaflik J.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0493
Subject(s) - medicine , mycophenolic acid , immunosuppression , surgery , mycophenolate , incidence (geometry) , corneal transplant , corneal transplantation , transplantation , physics , optics
Purpose The study aimed to evaluate the efficacy and safety of systemic immunosuppression with mycophenolate mofetil ( MMF ) to prevent corneal graft rejection after high risk penetrating keratoplasty. Methods One hundred ninety‐six consecutive patients who underwent high risk penetrating keratoplasty defined as the presence of deep vascularization in more than two quadrants, keratouveitis, emergency keratoplasties, and retransplantations were enrolled in the study. Ninety‐eight prospectively followed‐up patients were treated with MMF (with dose adjustment based on mycophenolic acid [ MPA ] serum concentration), and 98 patients were in the non‐ MMF ‐treated retrospectively assessed control group. Results During a mean of 24 months’ observation, immune reactions occurred in 8 cases (8%) and graft rejection with subsequent graft failure occurred in 3 cases (3%) in the MMF group. In the control group, graft rejection occurred in 76 cases (78%) and failure due to graft rejection occurred in 30 cases (31%). Kaplan‐Meier analysis showed that after a year 93% of the grafts in the MMF ‐treated group and 47% in the control group showed no immune rejection (p < 0.01, log‐rank test). Cox regression analysis showed that MMF treatment decreased the risk of graft rejection 11 times ( RR = 11, 95.0% CI 4.8–25, p < 0.0001). Among 98 MMF ‐treated patients, 13 had gastric discomfort, 3 developed leucopenia, and 2 had anemia that resolved after MMF dose reduction. Conclusions MMF treatment after high risk penetrating keratoplasty is safe and reduces the incidence of immune graft rejection and graft failure. Side effects were rare and reversible in all but one case.