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Uveal melanoma and other cancers
Author(s) -
Desjardins L.,
Villaret J.,
Cassoux N.,
LumbrosoLeRouic L.,
Levy C.,
Plancher C.,
Savigi A.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0474
Subject(s) - melanoma , medicine , cancer , breast cancer , oncology , retinoblastoma , cancer research , gene , biology , biochemistry
Purpose We evaluated in a retrospective study the frequency and nature of other cancers in uveal melanoma patients. Methods Patients and method A prospective registry of uveal melanoma patients is pêrformed in our center including usual datas on patients and tumor characteristics and since 2000 cancer past history. Each patient is followed during ten years after initial treatment and occurence of second cancer after uveal melanoma is registered. Results there are 6262 patients in the database with uveal melanoma and for 3934 history of previous cancer was registered. We had 548 cases of associated cancer: 423 had a past history of cancer before uveal melanoma was diagnosed and 102 patients développed a second cancer after the diagnosis of uveal melanoma. Cutaneous melanoma and renal carcinoma were found to be more frequent than expected. Conclusions Recent genetic improvments led to new discovery of germinal mutations responsible for cancer. As known for BRCA mutations and breast cancer or Rb1 gene and retinoblastoma, BAP 1 mutations has been found to predispose to mesothelioma, clear cells renal cancer and cutaneous and uveal melanoma. For young patients or patients with multiple cancers or family high frequency of cancer genetic counseling has became essential.