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Subretinal drusenoid deposits in an elderly population with age‐related macular degeneration ( MONTRACHET study: Maculopathy, Optic Nerve, nu TR ition, neurovasCular and HE arT diseases)
Author(s) -
Gabrielle P.H.,
DeLazzer A.,
Koehrer P.,
Devilliers H.,
Arnoult L.,
Danielle S.,
Binquet C.,
Tzourio C.,
Bron A.M.,
Creuzot C.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0464
Subject(s) - macular degeneration , medicine , maculopathy , ophthalmology , population , optic nerve , cohort , retinal pigment epithelium , neurovascular bundle , retinal , retinopathy , surgery , diabetes mellitus , endocrinology , environmental health
Purpose To determine the frequency of subretinal drusenoid deposits ( SDD ) in a French population of elderly patients presenting an age‐related macular degeneration ( AMD ) in the MONTRACHET study. Methods The three‐city study (3C) was a population‐based study including 9294 patients older than 65 years from three French cities (Dijon, Bordeaux and Montpellier) at baseline in 1999. After 10 years, the cohort of Dijon benefited from a complete ophthalmologic examination as part of the MONTRACHET study. Each patient underwent a non‐mydriatic retinophotography associated with a spectral‐domain OCT examination ( SD ‐ OCT ) of the macula. AMD classification was established according to the classification of the Multi‐Ethnic study of Atherosclerosis ( MESA ) for the retinophotography analysis and with the E3 CONSORTIUM classification for the SD ‐ OCT analysis. Patients with uninterpretable images of both eyes were excluded from statistical analysis. Results One thousand one hundred fifty three subjects were included. 62.7% were female and the mean age was 82.2 ± 3.8 years. With retinophotography analysis, the frequency of SDD was 1.9% (n = 38 eyes). With the SD ‐ OCT macular analysis, the frequency of SDD was 14.8% (n = 342). In patients presenting with SDD , 68.8% (n = 137) had a bilateral involvement. The relative risk ( RR ) of presenting SDD lesions in patients older than 80 years old was 2.6 (p < 0.001) and in women at 1.3 (p < 0.045). An interruption of the ellipsoide line and an alteration of the retinal pigment epithelium were statistically associated with the presence of SDD : RR = 5.9 (p < 0.001) and RR = 2.8 (p < 0.001), respectively. The average thickness of the subfoveal choroid was thinner in subjects presenting SDD (174.9 μ m with SDD vs 209.8 μ m without SDD , p < 0.001). Conclusions Few population‐based studies have established the frequency of SDD in an elderly population.