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Estimated cerebrospinal fluid pressure and trans‐lamina cribrosa pressure difference in open angle glaucoma. The Korea National Health and Nutrition Examination Survey 2009‐2012
Author(s) -
Lee S.H.,
Kwak S.W.,
Kang E.M.,
Hong S.,
Seong G.J.,
Kim C.Y.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0447
Subject(s) - cerebrospinal fluid pressure , medicine , glaucoma , intraocular pressure , ophthalmology , national health and nutrition examination survey , normal tension glaucoma , population , open angle glaucoma , body mass index , anesthesia , intracranial pressure , environmental health
Purpose To investigate associations of estimated cerebrospinal fluid pressure ( CSFP ) and trans‐lamina cribrosa pressure difference ( TLCPD ) with glaucomatous optic neuropathy in a population‐based setting. Methods A total of 6656 adults (≥40 years) who participated in the Korea National Health and Nutrition Examination Survey ( KNHANES ) from 2009 to 2012 were included. Subjects were divided into non‐glaucomatous and glaucomatous group, and glaucomatous subjects were further divided into normal tension glaucoma ( NTG ) group and high tension glaucoma ( HTG ) group. Based on a previous study with lumbar CSFP measurements, CSFP was estimated as CSFP (mmHg) = 0.55 Body Mass Index(kg/m 2 ) + 0.16 Diastolic Blood Pressure(mmHg)‐0.18 × Age(years)−1.91. TLCPD was calculated as intraocular pressure ( IOP )‐ CSFP . Differences in estimated CSFP and TLCPD were assessed between the non‐glaucomatous and glaucomatous groups. Results In the non‐glaucomatous population (n = 6016), mean estimated CSFP was 11.38 ± 3.11 mmHg and mean TLCPD was 2.54 ± 3.83 mmHg. When compared to the glaucoma group (n = 640), lower IOP (p < 0.001), higher CSFP (p < 0.001), and lower TLCPD (p < 0.001) were observed in the non‐glaucomatous group. Differences between glaucomatous subjects and non‐glaucomatous subjects in estimated CSFP , TLCPD , and IOP were greater for the HTG subjects than for the NTG subjects. Conclusions Estimated CSFP and TLCPD may play a significant role in pathogenesis of NTG and HTG .