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Comparison of the lamina cribrosa thickness of patients with unilateral branch retinal vein occlusion and normal subjects
Author(s) -
Sagong M.,
Lim S.H.,
Kim M.,
Chang W.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0403
Subject(s) - branch retinal vein occlusion , medicine , lamina , occlusion , ophthalmology , optic nerve , significant difference , retinal , anatomy , surgery , macular edema
Purpose We compared the lamina cribrosa thickness ( LCT ) of normal subjects and patients with unilateral branch retinal vein occlusion ( BRVO ), and investigated the correlation between the LCT and the BRVO subtypes. Methods A total of 46 eyes of 46 patients with naïve untreated BRVO and 31 eyes of 31 normal control subjects were included in this study. The occlusion site was divided into 2 BRVO types: arteriovenous crossing BRVO ( AV ‐ BRVO ) and optic nerve BRVO ( ON ‐ BRVO ). The optic nerve head ( ONH ) was scanned using enhanced‐depth imaging ( EDI ) with the Spectralis OCT system. The mean LCT was defined at the centers of the mid‐superior, central, and mid‐inferior horizontal B‐scans. The inter‐eye differences and intra‐eye differences in the LCT in BRVO were analyzed using the paired t‐test. Results The mean LCT of both eyes in the patients with BRVO was thinner than that of the normal subject eyes (both P < .001). Although the LCT of the BRVO ‐affected eyes were slightly thinner than that of the fellow eyes (237.0 µm vs. 241.4 µm ), there was no statistically significant difference. Moreover, there were no significant LCT differences according to site of occlusion ( AV ‐ BRVO 237.6 µm vs. ON ‐ BRVO 234.4 µm , P > .05). Conclusions The lamina cribrosa was thinner in both eyes of the unilateral BRVO patients than in those of the normal subjects, but there was no difference in the LCT regardless of the anatomical site of the occlusion. These findings suggest that BRVO and glaucoma may have a common structural pathogenic mechanism.