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Beta II tubulin as molecular marker of intraocular pressure in endothelial cells
Author(s) -
ProkoschWilling V.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0266
Subject(s) - regeneration (biology) , apoptosis , biology , regenerative medicine , microbiology and biotechnology , neuroscience , in vivo , glaucoma , in vitro , stem cell , intraocular pressure , anatomy , medicine , ophthalmology , genetics
Summary The human CNS ‐ like the adult mammalian CNS in general‐ lacks the capability to regenerate axons and restore neuronal tissue. After injury or in degenerative diseases like e.g. in glaucoma, neurons fail to regrow and reconnect with their target cells, frequently underlay apoptosis and are abnormally replaced. This regenerative failure in CNS remains an enormous scientific and clinical challenge. However under certain conditions neurons may regain the ability to regenerate in vivo and in vitro. One interesting group which shows enormous regenerative potential on retinal ganglion cells are the crystallins. We present our data on the regenerative potential of crystallins in experimental models.