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Inflammation, wound healing and tear proteomics in glaucoma
Author(s) -
Uusitalo H.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0247
Subject(s) - glaucoma , medicine , conjunctiva , wound healing , glaucoma surgery , ophthalmology , inflammation , extracellular matrix , trabecular meshwork , pathology , surgery , immunology , biology , microbiology and biotechnology
Summary Wound healing is a complex process involved in ocular surgery, trauma and pathogenesis of several eye diseases. Due to the delicate and sensitive structures of the eye wound healing is playing a essential role in ophthalmology. In glaucoma surgery well controlled wound healing process is as important for the creation of a functioning passage to aqueous humor out of the eye. The state of the ocular tissues is of great importance for the success of ocular surgeries. Chronic topical glaucoma medication is an important risk for the ocular surface disease. It is also a risk for the failure in glaucoma surgery. The mechanism of failing glaucoma surgery is related to the presence inflammatory cells, accumulation of extracellular matrix proteins in the conjunctiva and the site of surgery, activation of matrix metalloproteinases and their tissue inhibitors and accumulation oxidized lipids in the conjunctiva and around the site of operation and glaucoma shunts. Tear fluid proteome is a novel technique to get detailed information about the processes of the anterior surfaces of the eye and could easily be performed. It has also proven to be a promising technique for detecting biomarkers for ocular surface disease, ocular inflammation and predicting thus the success of glaucoma surgery.