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Angiography reveals novel features of the retinal vasculature in mice
Author(s) -
Ruberte J.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0242
Subject(s) - retinal , plexus , fluorescein angiography , anatomy , angiography , medicine , anastomosis , retinal artery , pathology , ophthalmology , radiology , surgery
Summary Here, we present a comprehensive characterization of the mouse retinal vasculature by SLO ‐ OCT fluorescein angiography. Using this clinical imaging technique, we report previously unrecognized variations in C57 BL /6J vascular anatomy. All layers of the mouse retinal vasculature could be readily visualized during fluorescein angiography by SLO ‐ OCT . Blood vessel density was increased in the deep vascular plexus ( DVP ) compared with the superficial vascular plexus ( SVP ). When we examined different regions of the SVP and DVP , no differences in capillary density were observed between the inferior and superior hemispheres, or between different regions of the SVP . However, a small, but significant increase in capillary density was detected in the temporal hemisphere of the DVP compared with the nasal hemisphere of the DVP . Arteriolar and venular typologies were established and structural differences were observed between venular types. Unexpectedly, the hyaloid artery was found to persist in 15% of C57 BL /6 mice, forming anastomoses with peripheral retinal capillaries.