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The CD 4/ CD 8 ratio in vitreous fluids is of high diagnostic value in sarcoisosis
Author(s) -
Maruyhama K.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0113
Subject(s) - sarcoidosis , uveitis , medicine , vitrectomy , cd8 , cd4 cd8 ratio , population , pathology , dermatology , immunology , ophthalmology , lymphocyte subsets , visual acuity , immune system , environmental health
Summary Sarcoidosis is an idiopathic inflammatory disorder involving multiple organs, and ocular manifestation is one of the common features. A well‐known immunological feature in sarcoidosis is an increased CD 4+ helper T cell type 1 lymphocyte subset in BALF . In this study, we investigated the vitreous lymphocyte subsets of sarcoidosis to elucidate the immunological features of this disorder in the eye. Our study enrolled 86 sarcoidosis patients. Diagnoses included 53 eyes with definitive sarcoidosis (D‐S) of 41 patients, 60 eyes with suspected sarcoidosis (S‐S) of 45 patients. Vitreous samples from the uveitis patients were analyzed with flow cytometry. Our result presented that the CD 4/ CD 8 ratio was high in the D‐S/S‐S in the vitreous samples. Moreover, a high CD 4 + population indicated sarcoidosis uveitis. Therefore, diagnostic vitrectomy using flow cytometric analysis may be a useful adjunct for the diagnosis of sarcoidosis, particularly in complex cases.