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Capsular opacification and accommodative lens refilling
Author(s) -
Koopmans S.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0089
Subject(s) - lens (geology) , posterior capsule opacification , lens capsule , capsule , ophthalmology , silicone , medicine , anatomy , biology , chemistry , visual acuity , phacoemulsification , paleontology , botany , organic chemistry
Summary After lens refilling with a silicone polymer, accommodation has been demonstrated in rhesus monkeys. However, coinciding with the development of capsular opacification the accommodative amplitude decreases to zero. Several strategies may be followed to prevent the development of capsular opacification. A straight forward strategy is the attempt to destroy remaining lens epithelial cells in the lens capsule by cytotoxic drugs. By isolating the lens capsular bag from the rest of the anterior chamber the lens capsule may be selectively treated with drugs. Our experiments in various animal models have shown that lens epithelial cells are very resistant to these treatments. This suggests that better strategies are needed. In further experiments we found that the choice of a proper biomaterial in the capsular bag may also significantly influence the capsular opacification response. Results of lens refilling with Hyaluronan and functionalized nanogels will be discussed.