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The corpus callosum in human binocularity and strabismus
Author(s) -
Ten Tusscher M.
Publication year - 2015
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2015.0019
Subject(s) - corpus callosum , stimulation , fixation (population genetics) , visual field , ocular dominance , neuroscience , retina , psychology , retinal , strabismus , stimulus (psychology) , anatomy , medicine , visual cortex , ophthalmology , population , cognitive psychology , environmental health
Summary Intercortical visual transfer has been shown important in mammalian binocularity. The present study aims at demonstrating intercortical visual callosal transfer in 16 human subjects using DTI , fMRI and connectivity. With fMRI brain activation was analysed during central and peripheral retinal stimulation. These were compared with right and left sided stimuli during RE and LE fixation. Results were analysed in a 2 × 2 × 2 ANOVA with p = 0.005. Callosal fiber tracts were visualised with DTI . With fMRI it showed that RE fixation is associated more with significant signal changes in the corpus callosum, both with right and left V1 co‐activation. Connectivity from the left V1 showed mostly de‐activation in the corpus callosum and activation if the eye is stimulated from the contralateral central area of the visual field. Callosal activity is associated stronger with stimulation of the temporal central retina and right eye fixation. The stronger trigger from the right eye is likely due to ocular dominance: during central stimulation of the temporal retina of the RE , activation in the left V1 is associated with de‐activation in the corpus callosum.