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Choroidal thickness and volume in healthy children messured by enhanced depth imaging optical coherence tomography
Author(s) -
HERRERA L,
PEREZ NAVARRO I,
CARAMELLO C,
ZABADANI K,
ALMENARA C,
PÉREZ D,
MARTINEZ M,
SANCHEZ A,
PINILLA I,
ESTEBAN O
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.t099.x
Subject(s) - emmetropia , optical coherence tomography , ophthalmology , intraclass correlation , choroid , medicine , repeatability , refractive error , reproducibility , mathematics , optometry , optics , visual acuity , retina , physics , statistics
Purpose To evaluate choroidal thickness during childhood using enhanced depth imaging (EDI) spectral‐domain optical coherence tomography (SD‐OCT), and its correlation with age, sex, axial length (AL) and refractive error (RE) Methods Cross‐sectional study in which 93 eyes of 93 healthy children were studied using a 25 A‐scans‐EDI SD‐OCT protocol. Choroidal thickness was segmented manually, and an ETDRS grid was applied to analyze choroidal thickness and volume in each of its nine sectors. Two observers independently studied 30 children to assess repeatability and reproducibility, using intraclass coefficient (ICC). Results We included 50 males and 43 females, with mean age of 9.62±2.89 years, mean refractive error (spherical equivalent) +0.03±2.22D and mean axial length (AL) of 23.19±13mm. Mean subfoveal choroidal thickness (SFCT) and volume was 314.22 ±55.48, and 0.25±0.04m3, respectively. SFCT was significantly thicker in the hyperopic group (AL 22.39±0.83mm). There were no statistically significant differences between myopic (AL 24.33±0.76mm) and emmetropic (AL 23.27±0.54mm) children, as well as between males and females. There was a weak, positive correlation between SFCT and age (r=0.259, p=0.012). Inter and intra‐observer ICC of the nine sector of the ETDRS grid ranged from 0.929‐0.991 and 0.992‐0.998, respectively. Conclusion Pediatric SFCT is greater in hyperopic children. The choroid appears to become thicker with age. Manual choroidal thickness segmentation by EDI SD‐OCT showed a high inter and intra‐observer repeatability