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Analyze of visual field indices in ocular hypertension: PROG‐F3 study
Author(s) -
DELBARRE M,
GIRAUD JM,
APTEL F,
EL CHEHAB H,
RENARD JP
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.t038.x
Subject(s) - medicine , ophthalmology , receiver operating characteristic , retrospective cohort study , visual field , statistical significance , surgery
Purpose To analyze visual field (VF) indices and their progression of patients treated for ocular hypertension (OHT). Methods This retrospective study concerned 27.4% of a bicentric cohort (121 eyes of 441). These eyes with normal VF and without clinical structural defect at inclusion were monitored and treated for OHT at least 9.7+/‐1.65yrs. Patients underwent every 6 months an eye examination and a reproducible VF testing (Humphrey Field Analyser, SITA Standard 24‐2, Carl Zeiss Meditec). At the end of follow‐up, patients who developed POAG were included in evolutive group and patients without functional defects were considered stable. MD, VFI, and their rate of progression were analyzed. Statistical analyse compared populations by a Student t‐test and diagnostic performance was assessed by sensitivity (Se), specificity (Sp) and area under receiver operating characteristic curve (AUROC). Results Evolutive group included 46 eyes and stable group included 58 eyes. Rate of progression of MD (dB/yr) for stable and evolutive groups were respectively ‐0.007 and ‐0.285 (p <0.001). Rate of progression of VFI (%/yr) for stable and evolutive groups were respectively ‐0.026 and ‐0.407 (p=0.001). Initial MD (dB) at beginning of follow up for stable and evolutive groups were 1.139 and 0.616 (p<0.001). Initial VFI (%) were 99.793 and 99.304 (p<0.001). AUC were, respectively, for MD and VFI rate of progression : 0.967 and 0.827. The best cut off value of AUROC was for MD rate of progression: ‐0.100 dB/yr (Se=93.5%, Sp=93.1%). Conclusion Rate of progression of MD and VFI in OHT evolutive group were higher than in OHT stable group. This study reports a higher diagnostic power for rate of progression of MD. It could be used to screen OHT patients at risk of POAG.