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Suggestion of optimal response criteria in patients with ocular adnexal mucosa associated lymphoid tissue lymphoma
Author(s) -
JUNG S,
PAIK JISUN,
YANG SW
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.s113.x
Subject(s) - medicine , lymphoma , magnetic resonance imaging , malignancy , malt lymphoma , complete response , surgery , nuclear medicine , radiology , chemotherapy
Purpose Ocular adnexal mucosa‐associated lymphoid tissue (MALT) lymphoma (OAML) has been recognized as most common primary orbital malignancy. However, little was known about the response criteria for OAML. Our aim was to suggest response criteria for nonconjunctival OAML, the response evaluation of which using the conventional response criteria is inappropriate. Methods A retrospective chart review of 34 eyes from 30 patients diagnosed with nonconjunctival OAML was conducted, focusing on the change in tumor size based on linear bi‐dimensional, and three‐dimensional methods in magnetic resonance imaging (MRI) of the orbit. The maximum tumor response period of each case was investigated, and the expected optimal response period was calculated using regression analysis. Results In the 30 evaluable patients, the median time taken for the maximum tumor response was 6 months (range, 3–18 months). More than 75% of patients attained a maximal tumor response in 6 months after initial therapy (median follow‐up period, 30 months; range, 15–77 months). Based on the regression analysis, it took 4.7 months for the maximum diameter (2r) of the tumor to decrease by 50% of the initial lesion size. Conclusion We cautiously suggest that the optimal response could be defined as a 50% reduction of the maximum diameter within 6 months of treatment initiation and that only observation without additional therapy is adequate for nonconjunctival OAML if an optimal response is achieved.