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Epidemiology of corneal ulceration and ocular surface disease among patients with Graves’orbitopathy
Author(s) -
KLYSIK A
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.s060.x
Subject(s) - medicine , stage (stratigraphy) , incidence (geometry) , complication , eye disease , corneal ulceration , disease , corneal disease , ophthalmology , graves' disease , surgery , dermatology , cornea , paleontology , physics , optics , biology
Purpose To determine the incidence of corneal ulceration and ocular surface disease among patients with active and inactive stage of Graves’ orbitopathy. Methods 678 patients with clinical evidence of moderate or severe Graves’ orbitopathy remaining under the care of Department of Ophthalmology of the Medical University of Lodz from January 2004 to April 2014. Average duration of the disease was 6.8 years. Average duration of follow‐up was 6.6 years. Episodes of corneal ulceration and ocular surface symptoms were analyzed. Results Corneal ulceration occurred in 2 patients with active stage of orbitopathy, and 6 patient in an inactive stage. One patient in active stage of the disease developed central corneal ulceration, and 7 patients ( 1 in the active stage, and 6 in an inactive stage) developed peripheral corneal ulceration. 5 patient developed ulceration at 9 o’clock in the right eye and 3 o’clock in the left and 2 patients developed inferior ulcer at 6 o’clock. The incidence rate of corneal ulceration in moderate to severe Graves’ orbitopathy is 0.174 %. Ocular surface symptoms were noted in 26% Conclusion Corneal ulceration is a very rare complication of Graves’ orbitopathy, more commonly occurring in the inactive stage of the disease. Ocular surface disease occurs in about one fourth of patients in an inactive stage of moderate and severe disease.