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Optic nerve oximetry mapping using a novel metabolic hyperspectral retinal camera
Author(s) -
DESJARDINS M,
SYLVESTRE JP,
TRUSSART R,
ARBOUR JD,
LESAGE F
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.f104.x
Subject(s) - hyperspectral imaging , retinal , optic nerve , pulse oximetry , optics , medicine , ophthalmology , computer science , materials science , artificial intelligence , physics , anesthesia
Purpose Oximetry measurement of the principal retinal vessels represents a first step towards understanding retinal metabolic state. Spectral imaging is expected to significantly enhance metabolic state evaluation via local fundus oximetry determination. In this preliminary study, we focus on the oximetry of the entire optic nerve head (ONH) microvasculature from datasets obtained with a novel metabolic hyperspectral retinal camera (MHRC). Methods Five healthy volunteers had retinal images captured between 490‐650 nm in steps of 5 nm using a prototype MHRC (Optina Diagnostics, Montreal, Canada) based on a tunable laser source that permits the selection of a specific wavelength (2 nm bandwidth) from a supercontinuum source. Each subject's data was fit to a model where oxy‐ and deoxyhemoglobin are the main absorbers and scattering is modeled by a log(1/wavelength) term. The fitted parameters were used to extract an estimation of oxygen saturation and total hemoglobin content. Results The local oximetry and hemoglobin content maps over the entire ONH microvasculature were extracted for all subjects from the spectral‐rich information. Physiologically plausible oxygen saturation values were obtained for all subjects over this region (mean 58 +/‐ 6 %). Conclusion The oximetry and hemoglobin content maps of the ONH microvasculature obtained with the MHRC could ultimately contribute to the diagnostic and optimal management of diseases affecting the ONH such as glaucoma.