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Predictive value of outer retina Enface OCT imaging in geographic atrophy progression
Author(s) -
GIOCANTIAUREGAN A,
TADAYONI R,
DOURMAD P,
MAGAZZINI S,
COHEN SY
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.f065.x
Subject(s) - ophthalmology , geographic atrophy , medicine , visual acuity , macular degeneration , retina , retinal , atrophy , pathology , biology , neuroscience
Purpose To determine wether there was a correlation between hypo reflective area in Enface OCT of outer retina at baseline, and geographic atrophy (GA) area 1 year later in dry age‐related macular degeneration (AMD) Methods Retrospective study. We included all patients who underwent a clinical examination for dry AMD from July to November 2013 and who had macular captured Enface OCT. Eyes with previously treated wet AMD were excluded. We analysed hypo reflectivity on Enface SD‐OCT extraction (Cirrus 2, Carl Zeiss Meditec,Dublin) of the outer retina 20 µm above retinal pigmented epithelium (RPE), corresponding to the disruption of ellipsoid line (EZ), and extraction below RPE corresponding to GA, the speed of progression of these 2 parameters, the pattern of these areas, best corrected visual acuity (BCVA) on ETDRS scale, and foveal involvement in GA. Our endpoint was the correlation between the difference area EZ‐GA and GA enlargement over 1 year on Enface OCT. Our secondary endpoint was the pattern similarities between both of these parameters. Results We included 38 eyes of 31 patients with dry AMD, mean age was 84,9 years. At baseline, mean size of GA area was 7.1 mm2, mean size of hypo reflectivity was 9.28 mm2, fovea was involved in GA in 49% of cases, BCVA was 64.2 letters. One year later, mean size of GA area was 9.2 mm2, fovea was involved in 54% of cases, BCVA was 58.8 letters. The rate of progression of GA was 2.04 mm2 per year. The difference EZ‐GA at baseline and GA enlargement were not strongly correlated. The pattern of EZ disruption on Enface OCT was correlated in more than 2/3rd of cases with the pattern of GA 1 year later. Conclusion EZ disruption and GA 1 year later are not constantly correlated