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Evaluation of two methods for measurements of macular pigment optical density (MPOD)
Author(s) -
BIRKELDH U,
WAHLBERG RAMSAY M,
NILSSON M,
BRAUTASET R
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.f060.x
Subject(s) - lutein , zeaxanthin , optical density , ophthalmology , medicine , chemistry , carotenoid , food science
Purpose To evaluate the outcomes of two methods for measurements of macular pigment optical density (MPOD). Methods In 33 subjects (mean age 51.85 years ±17.79; 4 men and 29 women), without any signs of ocular pathologies, MPOD was measured in the right eye using single‐wavelength reflectometry (Visucam 500) and heterochromatic flicker photometry (MacuLux®). In 13 subjects with discrete signs of age‐related macuolopathy (ARM), i.e., soft drusen and/or hyper‐/hypopigmentation of the retinal pigment epithelium (RPE), MPOD was measured after 6 and 12 methods of supplementation with MacuShield® (lutein 10 mg and zeaxanthin 2 mg and the non‐dietary carotenoid meso‐zeaxanthin 10 mg). Results There was a statistical significant difference (p<0.001) between the average maximum MPOD in the healthy subjects measured with the Visucam (0.384 ±0.049) and with the Maculux® (0.559 ±0.133). No correlation (r2= 0.089, p=0.09) was found between the two techniques. In the 13 subjects, treated with Macushield, the Visucam measurements showed a statistically significant MPOD reduction (p<0.0005) while a significant increase (p<0.0045) in MPOD was found with the MacuLux®. Conclusion The results from this study indicate that measurements of MPOD with different techniques do not correlate and that the Visucam seems unable to detect the increase in macular pigment after intake of supplementation.