Premium
Effect of a single intravitreal injection of anti‐VEGF agents on retinal arteriolar caliber in mini pig eyes
Author(s) -
MANGIORIS G,
PETROPOULOS I,
MENDRINOS E,
POURNARAS C
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.f059.x
Subject(s) - ranibizumab , pegaptanib , retinal , ophthalmology , medicine , vasoconstriction , bevacizumab , caliber , anesthesia , chemotherapy , materials science , metallurgy
Purpose The aim is to investigate the short‐term effect of a single intravitreal bevacizumab, ranibizumab or pegaptanib sodium injection on the retinal arteriolar caliber in minipigs. Methods 15 eyes received an intravitreal injection: bevacizumab 1,25mg (n=5), ranibizumab 0,5mg (n=5) and pegaptanib sodium 0,3mg (n=5). The diameter of the retinal arterioles was measured in vivo with a Retinal Vessel Analyzer (RVA) every 15 minutes for 2 hours. Results After the injection of bevacizumab statistical significant vasoconstriction was reached 1h after injection (p< 0.01) and persisted until the end of the measurements (2h). Although there appears to be a trend towards vasoconstriction after ranibizumab injection, analysis of measurements indicate that statistical significance (p<0.05) is reached only 1h 30min following injection. After the injection of pegaptanib sodium injection revealed no vasomotor effect of the substance. (p>0.05) Conclusion The results suggest that intravitreal injection of anti‐VEGF that blocks all isoforms of VEGF, induces retinal vasoconstriction. Further studies with a larger number of subjects would be helpful in establishing more clearly the effect of intravitreal anti‐vascular endothelial growth factor treatment on retinal vessel diameters.