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Retinal vessel oxygen saturation in diabetic patients with and without cardiovascular disease and its association with renal function
Author(s) -
HEITMAR R,
BLANN A
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.f046.x
Subject(s) - medicine , diabetes mellitus , blood pressure , retinal , oxygen saturation , renal function , cardiology , type 2 diabetes , disease , ophthalmology , endocrinology , oxygen , chemistry , organic chemistry
Purpose To explore the association of renal function and retinal vessel oxygen saturation in patients suffering from diabetes and cardiovascular disease. Methods We examined three groups of patients (1: Diabetics, 2: Diabetics with cardiovascular disease and 3: patients suffering from cardiovascular disease without diabetes). All patients Intraocular Pressure, Systemic Blood Pressure and Dual Wavelength Retinal Vessel Oxygen Saturation (arterial and venous vessel saturation and a‐v saturation difference) and Retinal Vessel Calibers were measured following phlebotomy to determine their HbA1c levels. Markers of renal function (ceratinine, eGfr and uACR) were measured in all patients. Results All three groups were age matched (1: 63 (10)yrs; 2: 64 (9)yrs and 3:65 (10)yrs). Unsurprisingly HbA1c was significantly different between groups (p<0.001), while Intraocular Pressure and Systemic Blood Pressure variables were comparable. While arterial and venous oxygen saturation were comparable between groups, the cardiovascular group had the lowest venous saturation, resulting in the highest a‐v values but this was not statistically significant. Markers of renal function showed a statistically significant correlation with a‐v saturation values in patients suffering from both: diabetes and cardiovascular disease (eGfR and a‐v‐saturation: r=0.65, p=0.001) but not in those suffering from cardiovascular disease alone (r=0.36, p=0.063). Conclusion Retinal vessel oxygen saturation parameters appear to be associated with renal function in patients suffering from both diabetes and cardiovascular disease.