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FRO 2014: Proteomic analysis of posterior capsular plaques and capsules in developmental cataracts
Author(s) -
VAN LOOVEREN J
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.4765.x
Subject(s) - dysgenesis , cataracts , medicine , capsule , lens capsule , cataract surgery , posterior capsule opacification , lens (geology) , ophthalmology , pathology , anatomy , biology , intraocular lens , visual acuity , paleontology , botany , phacoemulsification
When operating children with developmental cataract surgeons are often confronted with an opaque plaque adhering to the inside of the posterior capsule. In a previous study using immunohistochemical analysis we were able to demonstrate that these posterior capsular plaques can contain collagen type II, a type of collagen which was never demonstrated in a human lens before. We also exposed the strong adherence of the anterior hyaloid membrane (containing collagen type II) to the center of the posterior lens capsule indicating a dysgenesis of Berger’s space in these specific cataract cases. The purpose of this study is to increase knowledge of the biochemical composition of these posterior capsular plaques and capsules in developmental cataract by using proteomic approaches. We believe these insights will be beneficial to understand cataract formation in these children and ultimately will improve the surgical outcome of cataract surgery in these particular cases with generally worse prognosis.