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Diabetic retinopathy and estimated cerebrospinal fluid pressure. The Beijing eye study 2011
Author(s) -
JONAS J,
WANG N,
XU L,
XU JIE,
WANG Y,
YOU Q
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.4747.x
Subject(s) - medicine , cerebrospinal fluid pressure , diabetes mellitus , blood pressure , diabetic retinopathy , retinopathy , cardiology , population , diastole , anesthesia , ophthalmology , cerebrospinal fluid , endocrinology , environmental health
Purpose We tested the hypothesis whether prevalence and severity of diabetic retinopathy are associated with cerebrospinal fluid pressure (CSFP) Methods The population‐based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.69.8 years. Based on a previous study with lumbar cerebrospinal fluid pressure (CSFP) measurements, CSFP was calculated as CSFP[mmHg]=0.44xBody Mass Index[kg/m2]+0.16 Diastolic Blood Pressure[mmHg]–0.18xAge[Years]‐1.91. Results In binary regression analysis, presence of diabetic retinopathy was significantly associated with higher levels of HbA1c (P<0.001), higher blood concentration of glucose (P<0.001), longer known duration of diabetes mellitus (P<0.001), higher systolic blood pressure (P<0.001;), lower diastolic blood pressure (P<0.001), and higher CSFP (P=0.002). Severity of diabetic retinopathy was significantly associated with higher HbA1c value (P<0.001), higher blood concentration of glucose (), longer known duration of diabetes mellitus (P<0.001), lower level of education (P=0.001), lower diastolic blood pressure (P=0.002), higher systolic blood pressure (P=0.006), and higher CSFP (P=0.006). Conclusion Higher prevalence and severity of diabetic retinopathy were associated with higher estimated CSFP after adjusting for systemic parameters. Higher CSFP through a higher retinal vein pressure may lead to more marked retinal venous congestion and vascular leakage in diabetic retinae.