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Growth factor and interleukin concentration in amniotic membrane suspension (AMS) and amniotic tissue homogenates (AMTH)
Author(s) -
SZENTMARY N,
STACHON T,
BISCHOFF M,
HUBER M,
ZAWADA M,
LANGENBUCHER A,
SEITZ B
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.4735.x
Subject(s) - interleukin , interleukin 8 , interleukin 1β , epidermal growth factor , amniotic fluid , andrology , chemistry , medicine , immunology , biology , cytokine , biochemistry , pregnancy , fetus , receptor , genetics
Application of AMS or AMTH eye drops was suggested as a potential non‐surgical treatment alternative of therapy resistant corneal epithelial defects. We determined the concentration of growth factors EGF and FGFb and interleukins IL‐6 and IL‐8 in AMS and AMTH following different preparation methods. In AMTH EGF concentration was about 1.7‐17x and FGFb concentration about 1.2‐8.5x higher than in AMS. With higher EGF and FGFb concentrations and lack of IL‐6 and IL‐8 in AMTH, its use may be more appropriate in treatment of corneal epithelial defects. However, the most effective preparation method and the harvesting timepoint are yet to be determined.