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FRO 2014: ROCK as a potential target in the treatment of different retinopathies
Author(s) -
HOLLANDERS K,
SPILEERS W
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.4664.x
Subject(s) - retinopathy of prematurity , neuroprotection , medicine , diabetic retinopathy , in vivo , vegf receptors , angiogenesis , ischemia , inflammation , retinopathy , pharmacology , ophthalmology , cancer research , endocrinology , biology , diabetes mellitus , pregnancy , genetics , microbiology and biotechnology , gestational age
The aim of this project is to investigate the therapeutic effect of ROCK‐inhibition in two mouse models for ischemia‐related retinopathy, diabetic retinopathy (DR) and retinopathy of prematurity (ROP). 1) The first objective of this project is to elucidate the in vivo role of ROCK on the process of inflammation and angiogenesis in ischemic retinopathies. Therefore, the efficacy of a potent ROCK inhibitor will be compared to anti‐VEGF therapy (DC101), using two different mouse models. 2) The second objective is to evaluate the possible neuroprotective effect of ROCK inhibition.