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Cavitary retinoblastoma: clinical features and treatment outcome
Author(s) -
HADJISTILIANOU T,
DE FRANCESCO S,
BORRI M,
GALLUZZI P,
DELUCA MC,
BRACCO S
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.4643.x
Subject(s) - medicine , retinoblastoma , radiation therapy , chemotherapy , external beam radiotherapy , surgery , demographics , radiology , brachytherapy , biochemistry , chemistry , demography , sociology , gene
Purpose To describe the ophthalmoscopic features of seven cavitary retinoblastomas and treatment outcome Methods Patient demographics, tumor characteristics, ultrasounds, OCT and MRI findings and response to treatment (systemic chemotherapy, intrarterial chemotherapy, focal therapy ,external beam radiotherapy)were recorded. Results Two cases were bilateral, three cases were unilateral. All cases were unifocal. The median age at first observation was 18 months. No vitreous or subretinal seeds were present. Two tumors were treated with systemic CH followed by IA‐CH ; one tumor with systemic CH and radiotherapy; four tumors with IA‐CH.All cases received adjuvant photocoagulation. Globe salvage was achieved in six out of seven cases (85.7%) Three months after treatment the mean reduction in tumor thickness was 19%. During a mean follow‐up of 18 months one case recurred and one gave rise to subretinal seeds. Conclusion Cavitary retinoblastomas do not show a substantial decrease in size after treatment and do not display dramatic ophthalmoscopic changes.