Premium
Electrospun nanofibrous scaffolds and corneal tissue engineering
Author(s) -
SALEHI S,
BAHNERS T,
GUTMANN J,
FUCHSLUGER T
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.4631.x
Subject(s) - cornea , tissue engineering , extracellular matrix , ex vivo , regeneration (biology) , stromal cell , biomedical engineering , corneal transplantation , in vivo , materials science , microbiology and biotechnology , medicine , pathology , ophthalmology , biology
Generation of a tissue‐engineered cornea composed of biomaterials and cells will reduce dependency on the short supply of donor corneal tissue. In the last decade, the supply of viable donor tissue for corneal transplants is relatively less than the demand for donor corneal tissue. A tissue‐ engineered cornea that incorporates cells with a biocompatible and aligned nanofibrous scaffolds that replicates the stromal extracellular matrix will be an optimal alternative to synthetic replacements and donor tissue. Biodegradable aligned electrospun substitutes of a tissue‐ engineered cornea would also serve as an in‐ vivo and ex‐vivo platform for investigating the mechanisms of corneal diseases, regeneration of corneal cell layers and human cellular responses to new ophthalmic drugs.