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Prospective evaluation of intense pulsed light (IPL) therapy for meibomian gland dysfunction (MGD)
Author(s) -
CRAIG JP,
TURNBULL PR,
CHEN A
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.4452.x
Subject(s) - medicine , ophthalmology , placebo , meibomian gland , prospective cohort study , intense pulsed light , eyelid , cornea , surgery , pathology , alternative medicine , dermatology
Purpose To evaluate the effect of intense pulsed light (IPL) applied to the periocular area for meibomian gland dysfunction (MGD) in a prospective, double‐masked, placebo‐controlled, paired‐eye study. Methods Twenty‐eight participants (aged 45±16 years, 68% female) underwent IPL treatment (E>Eye, E‐Swin, France), with homogeneously sequenced light pulses delivered to one eye (treated eye, randomised, masked), while placebo treatment was performed on the partner eye (control eye) on 3 occasions following baseline (BL) evaluation; on Day 1, Day 15, and Day 45. Lipid layer grade (LLG), non‐invasive tear breakup time (NIBUT), tear evaporation rate (TER), tear meniscus height (TMH) and subjective symptom score (SPEED) were compared to BL and control values at each visit. Results LLG improved significantly from BL to Day 45 in the treated eye (p=0.0002), but not control eye (p=0.714) with an increase of 1.5 grades exhibited by 75% of treated eyes by Day 45. NIBUT also improved significantly from BL to Day 45 in the treated (p<0.0001), but not control eye (p=0.056). NIBUT in the treated eye was significantly longer than that in the control eye at Day 45 (14.1 ± 9.8s vs 8.6 ± 8.2s, p<0.0001). TER was not significantly lower at Day 45 compared to BL in the control eye (p=0.165), but approached significance in the treated eye (p = 0.080). No change in TMH was noted from BL in either eye at Day 45 (p>0.05). SPEED scores improved at each visit in both the treated (p<0.0001) and control eye (p=0.002), with 86% of participants noting reduced symptoms in the treated eye by Day 45. Conclusion IPL with multiple sculpted pulses shows therapeutic potential for MGD, statistically and clinically improving tear film quality and reducing symptoms of dry eye.Commercial interest