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Terrien's marginal degeneration: Nordic collaborative study
Author(s) -
KURKINEN M,
DROLSUM L,
FAGERHOLM P,
HJORTDAL J,
HOLOPAINEN J
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.4428.x
Subject(s) - medicine , asymptomatic , university hospital , corneal disease , astigmatism , ophthalmology , disease , dermatology , optometry , pediatrics , surgery , pathology , cornea , physics , optics
Purpose The objective of our study is to describe the clinical and imaging features of Terrien's marginal degeneration (TMD) and subsequently to define the clinical diagnostic criteria for TMD. Lastly we aim to detect the natural course of this disease. Methods Our study design is cross‐sectional and includes TMD patients diagnosed in Helsinki University Eye Hospital, Aarhus University Hospital, Sahlgrenska University Hospital and Oslo University Hospital by corneal specialists. Analysis include gender distribution, age, symptoms, as well as clinical, topographical and imaging findings. The analysis is based on descriptive variables due the limited sample size. Results We present here clinical findings of Finnish TMD patients. All patients were asymptomatic and did not suffer from any systemic autoimmune diseases. Topographical analysis showed high astigmatism due to severe corneal thinning as evidenced by optical coherence tomography imaging. Conclusion TMD is a bilateral corneal disease. Patients are commonly asymptomatic and visit an ophthalmologist because of deteriorated vision due to increasing astigmatism. TMD is thus diagnosed by coincidence. TMD does not seem to be associated with any systemic autoimmune diseases and it is commonly non‐progressing.