Premium
Physiology of retinal oxygen extraction
Author(s) -
SCHMIDL D
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.3713.x
Subject(s) - retinal , diabetic retinopathy , oxygen saturation , glaucoma , retina , oxygen , ophthalmology , blood flow , medicine , oxygen metabolism , retinopathy of prematurity , oxygenation , biology , neuroscience , chemistry , diabetes mellitus , endocrinology , genetics , organic chemistry , gestational age , pregnancy
It has been hypothesized that several ocular diseases such as glaucoma or diabetic retinopathy are associated with impaired ocular blood flow and altered oxygen supply of the retinal tissue. The recent development of new and sophisticated instruments for the non‐invasive measurement of retinal oxygen saturation allow now for the investigation of retinal oxygenation in both healthy and disease. In addition, combination of these technologies with non‐invasive measurements of retinal blood flow can provide data on oxygen extraction, which in turn allows for the estimation of oxygen consumption of the tissue. This talk aims to summarize our current understanding of the physiological mechanisms regulating the oxygen supply of the ocular tissues. In addition, recently introduced methods for the estimation of oxygen extraction of the retinal tissue with be presented. Finally, the possible clinical applications for these emerging techniques will be discussed.