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Assessment of retinal blood oxygen saturation in patients with primary open angle glaucoma
Author(s) -
SHAHIDI AM,
HUDSON C,
PATEL SR,
TAYYARI F,
FLANAGAN JG
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.3712.x
Subject(s) - retinal , ophthalmology , medicine , open angle glaucoma , oxygen saturation , glaucoma , significant difference , cardiology , oxygen , chemistry , organic chemistry
Purpose: To investigate retinal SO2 in POAG using a retinal hyperspectral camera (HRC). Method: 9 controls and 15 POAG patients were imaged using a prototype HRC, at wavelengths between 500‐610nm. POAG was classified as mild (mean deviation [MD]<‐6) or moderate to severe (MD≥‐6). Arteriolar, venular and arterio‐venous (AV) SO2 difference values were compared between the groups and the correlation with MD was assessed. Result: Mean SO2 values were 93±1.55 and 55.37±2.57 for arterioles and venules respectively in controls and 94.74±2.75 and 58.10±8.85 in the POAG group. No significant differences were found between the two groups (p=0.13 arterioles, p=0.42 venules). AV difference was also not significantly different (p=0.78). In patients with MD≥‐6, significantly higher venular SO2 (p=0.005) and significantly lower AV differences (p=0.01) were found compared to MD<‐6 and controls. No differences were found for arteriolar SO2 (p=0.31). Significant correlations were found between venular SO2 and AV differences with MD (p=0.02 and p=0.03). Conclusion: Patients with moderate to severe POAG have higher venular SO2 and lower AV differences indicating a potential association with decreased oxygen extraction from the retinal capillaries.