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Confocal microscopy and optical coherence tomography imaging of corneal dystrophies
Author(s) -
WYLEGALA E
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.3635.x
Subject(s) - optical coherence tomography , confocal microscopy , confocal , corneal diseases , corneal dystrophy , pathological , medicine , microscopy , pathology , cornea , ophthalmology , optics , physics
Corneal dystrophies are the group of hereditary, slowly progressive disorders affecting all corneal layers. In the past, histological examination was crucial in proper diagnosis of corneal dystrophies. In recent years, non invasive optical imaging systems such as optical coherence tomography (OCT) and confocal microscopy (CM) along with genetic testing have become a new standard procedures in the diagnostic process. Advances in diagnosis and treatment of corneal dystrophies including genetic analysis and confocal microscopy findings were included in the IC3D classification in 2008. The lecture summarizes the basic principles of the confocal microscopy and optical coherence tomography. It describes the pathological corneal changes revealed by slit lamp and histological examination in relation to non contact imaging techniques. The structural changes observed with the histological methods give an account and provide an explanation for pathological changes demonstrated by the OCT and CM. This may allow for a better understanding of the pathological process involved in the corneal dystrophies progression.