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Reconstitution of a corneal endothelium by intracameral injection of cultured endothelial cells
Author(s) -
BRUNETTE I,
BOSTAN C,
THERIAULT M,
FORGET K,
PROULX S
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.3433.x
Subject(s) - corneal endothelium , endothelium , medicine , corneal transplantation , ophthalmology , endothelial stem cell , transplantation , corneal graft , in vivo , cornea , surgery , in vitro , chemistry , biology , biochemistry , microbiology and biotechnology
The only currently available treatment for irreversible corneal endothelial failure is allo‐transplantation, which is overshadowed by optical distortion of the posterior surface, postoperative donor corneal endothelial cells attrition and risk of rejection. Assessment of the in vivo functionality of a corneal endothelium reconstituted by the injection of corneal endothelial cells in the anterior chamber of an endothelial deficiency model allows to consider cell‐injection as a possible therapy for corneal endotheliopathies.