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Learning about herpes infections by using animal models
Author(s) -
ATHERTON S
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.3243.x
Subject(s) - disease , animal model , retinitis , human disease , medicine , presentation (obstetrics) , immunology , pathology , virus , human cytomegalovirus , endocrinology , radiology
Ocular infections caused by members of the herpesvirus family may have serious and sometimes, sight‐threatening, consequences. As has been for so many disease processes, animal models have been used to better understand the pathogenesis of herpetic keratitis and retinitis in human patients. While no animal model has absolute fidelity to its human counterpart, careful interpretation and extrapolation of results from animal studies may provide valuable information/insight about the pathogenesis of human disease. This presentation will provide an overview of animal models of keratitis and retinitis, summarize the strengths and weaknesses of the models, and discuss how what has been learned from these models has advanced our knowledge of the mechanisms of human ocular disease and/or has led to new therapeutic approaches to these diseases.