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Matrix wound healing in the optic nerve
Author(s) -
O'BRIEN C
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.2774.x
Subject(s) - wound healing , matrix (chemical analysis) , optic nerve , medicine , ophthalmology , surgery , chemistry , chromatography
The risk factors associated with optic disc cupping in glaucoma include intraocular pressure and ocular perfusion pressure. The mechanisms of optic disc cupping result in significant extra‐cellular matrix alterations for the lamina cribrosa. A number of cell types play a key role in this ECM re‐modelling including lamina cribrosa cells and astrocytes. A dysfunction in these cell types include high intra‐cellular calcium, mitochondrial dysfunction, and oxidative stress. A greater understanding of the mechanisms involved lead to new therapeutic approaches.