Premium
The role of inflammation and extracellular matrix in the wound healing after glaucoma surgery
Author(s) -
UUSITALO H
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.2773.x
Subject(s) - wound healing , glaucoma , medicine , trabeculectomy , inflammation , glaucoma surgery , extracellular matrix , conjunctiva , matrix metalloproteinase , ophthalmology , pathogenesis , surgery , pathology , immunology , microbiology and biotechnology , biology
Wound healing is a complex process involved in ocular surgery, trauma and pathogenesis of several eye diseases. Due to the delicate and sensitive structures of the eye wound healing is playing a essential role in ophthalmology. In glaucoma surgery well controlled wound healing process is as important for the creation of a functioning passage to aqueous humor out of the eye. There are growing body of evidence that the preoperative state of the conjunctiva is of great importance for the success of glaucoma surgery. This has been demonstrated in trabeculectomy and in non‐penetrating glaucoma surgery like deep sclerectomy. The presence of inflammatory cells in the conjunctival specimens taken during the surgery and the success of the operation points out the role of inflammation in wound healing processes. The data obtained from the specimens taken from the eyes with good and poor ontrol of IOP after glaucoma implants demonstrating the accumulation of extracellular components and activated myofibroblasts further indicates the activation of the whole wound healing cascade. The role of matrix metalloproteinases and their endogenous inhibotors (TIMP's) is evident but seem to be rather specifically involving certain MMP's.Commercial interest