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Innate immunity and retinal angiogenesis
Author(s) -
XU H
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.2751.x
Subject(s) - innate immune system , retinal , diabetic retinopathy , angiogenesis , macular degeneration , immune system , immunity , medicine , retina , diabetes mellitus , immunology , biology , neuroscience , ophthalmology , endocrinology
The innate immune system plays an important role in tissue homeostasis under chronic insult conditions such as ageing and diabetes. Uncontrolled or dysregulated innate immune response to retinal insults in the elderly or diabetes may result in retinal pathologies such as age‐related macular degeneration (AMD) or diabetic retinopathy (DR). Patients suffering from AMD or DR may lose visual function due to the abnormal growth of new blood vessels. Growing evidence suggests that innate immune cells are critically involved in retinal angiogenesis. The role of monocytes/macrophages and neutrophils in retinal angiogenesis will be discussed.