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Clinical experiences with short‐term delivery of azithromycin in conjunctival inflammation and MGD
Author(s) -
DOAN S
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.2676.x
Subject(s) - azithromycin , blepharitis , medicine , meibomian gland , rosacea , dermatology , clinical trial , antibiotics , keratoconjunctivitis , inflammation , surgery , eyelid , biology , microbiology and biotechnology , acne
Azithromycin is an azalide antibiotic, derived from the macrolides family. This is a good candidate for treating meibomian gland dysfunction and MGD‐related ocular surface inflammation for several reasons : (1) its bacterial spectrum is mainly oriented against gram positive cocci ;(2)it has a long tissular and lachrymal half life, because it accumulates in the intracellular compartment ; (3) it has anti‐inflammatory, anti‐MMP and lipase inhibiting properties. We tested azithromycin 1.5% eyedrops in blepharitis patients in two clinical studies. ‐ The first study was a multicenter randomized placebo controlled study, involving chronic moderate‐to‐severe blepharitis patients. ‐The second study was a single center non controlled prospective study in children suffering from ocular rosacea with chronic phlyctenular keratoconjunctivitis. In both studies, topical azithromycin was effective in reducing signs and symptoms. We will discuss the results of these studies in detail, and provide practical clinical schemes for the use of this innovative treatment.Commercial interest