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Genome‐wide association studies for the identification of keratoconus susceptibility regions
Author(s) -
HYSI P
Publication year - 2014
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2014.2462.x
Subject(s) - keratoconus , genetic architecture , identification (biology) , genetic association , biology , genome wide association study , genetics , disease , population , phenotype , evolutionary biology , cornea , computational biology , single nucleotide polymorphism , medicine , genotype , gene , pathology , neuroscience , ecology , environmental health
Consensus seems to be building that most diseases are of complex nature and the result of interaction of a polygenic architecture with the environment. A great deal on the genetic architecture of the disease can be learned from population‐based and family studies. This presentation will explore the influence of heritable factors over keratoconus as well as shared genetic elements that influence both abnormal cornea and other phenotypic anomalies of the eye.