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Structure function relationship: Specific index of ganglion cell complex assessment of 2 spectral domain OCT and standard automated perimetry
Author(s) -
EL CHEHAB H,
DELBARRE M,
FENOLLAND JR,
MARéCHAL M,
ZERROUK M,
FRANCOZ M,
OUANEZAR S,
GIRAUD JM,
MAÿ F,
RENARD JP
Publication year - 2013
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2013.t055.x
Subject(s) - ophthalmology , glaucoma , medicine , pearson product moment correlation coefficient , optical coherence tomography , optometry , optics , mathematics , statistics , physics
Purpose To investigate structure function relationship between specifics parameters of structural damage analyzed by OCT RTVue100 (Optovue, Inc.) and CirrusHD‐OCT (Carl Zeiss Meditec) with functional parameters of standard automated perimetry (SAP). Methods 143 open angle glaucoma and 43 control eyes were included. They underwent a macular grid exam with RTVue100, CirrusHD‐OCT and 24°2 and 10°2 SAP (Humphrey SITA‐standard). Specifics structural parameters analyzed were Global and Focal Loss Volume (GLV and FLV) with RTVue, average and minimum Ganglion Cell and Inner Plexiform Layer (GCIPL) thickness with CirrusHD‐OCT. Functional parameters collected were MD, PSD and VFI for 24°2 SAP and MD and PSD for 10°2 SAP. A Student t‐test was performed to compare parameters and a logistic regression to calculate Pearson coefficient (r) studying correlation between structural and functional parameters. Results Glaucoma group had a significant functional (in 24°2 and 10°2 SAP) and structural impairment compared to control. Logistic regression analysis found a linear correlation between structural and functional parameters. The highest Pearson coefficient with OCT RTVue was between FLV and PSD in 24°2 SAP (r=0.72) and for CirrusHD‐OCT between minimum GCIPL and PSD in 24°2 SAP (r=0.56). Conclusion This study objectives a strucutre function relationship between specifics focal structural indices (FLV and GCIPL‐Min) assessed with these 2 SD‐OCT and functional (PSD) parameters damage. It would be interesting to confirm this new approch of SFR with these specific structural parameters.