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Nanoparticles for drug delivery to the retina
Author(s) -
STEFANSSON E
Publication year - 2013
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2013.4233.x
Subject(s) - drug , drug delivery , penetration (warfare) , mucoadhesion , eye drop , ophthalmology , nanoparticle , medicine , materials science , pharmacology , drug carrier , nanotechnology , operations research , engineering
We have developed a drug delivery platform based on cyclodextrin nanoparticles in eye drop suspensions. The nanoparticles increase drug solubility, extend mucoadhesion and penetration into the eye. High concentrations of drug in the tear film for extended periods of time allow for greatly increased penetration into the eye and relatively less washing into the nasolacrimal apparatus. Dexamethasone nanoparticle eye drops are effective against diabetic macular edema and uveitis. Cyclodextrin nanoparticle eye drops allow drug treatment of retinal disease with eye drops.