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Mechanism of fluid accumulation
Author(s) -
WOLFENSBERGER TJ
Publication year - 2013
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2013.3611.x
Subject(s) - choroid , retina , retinal pigment epithelium , mechanism (biology) , retinal , homeostasis , ophthalmology , microbiology and biotechnology , biology , neuroscience , medicine , physics , quantum mechanics
Purpose: To characterise the cellular mechanisms of fluid flow in the retina in view of its clinical implications. Background: Retinal fluid homeostasis is effected by a whole host of mechanisms that reside both in the retinal pigement epithelium, in the choroid and in the retina. In a physiological state there is a constant flow of fluid out of the intraretinal and subretinal space into the choroid, of which about 70% is effected via active transport mechanisms within in the retinal pigment epithelium. In case these Results: This presentation will summarise the latest data on how fluid homeostasis is maintained within the retina and how these mechanisms underly the evolving phramacological treatment modalities for exudative maculopathies. Conclusion: The understanding of the cellular mechanisms that govern retinal fluid flow is crucial to the cinical application of medical treatments against exudative maculopathies. .