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Cell biological mechanisms of wound healing
Author(s) -
JÄRVINEN T
Publication year - 2013
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2013.2774.x
Subject(s) - wound healing , regenerative medicine , tissue repair , organism , regeneration (biology) , inflammation , scar tissue , biology , medicine , regenerative process , tissue remodeling , tissue engineering , pathology , microbiology and biotechnology , stem cell , immunology , surgery , biomedical engineering , paleontology
Purpose Tissue repair is among the most complex biological processes that occur during human life. After an injury, multiple biological pathways become activated and are coordinated through three distinct phases of inflammation, proliferation and maturation to yield the reparative response. What distinguishes different tissues in their response to insult is that some tissues, such as bone, can regenerate and replace the injured tissue with tissue that is identical to one that existed there before, whereas most tissues, including human skin, heal by a repair process where the original tissue is replaced by non‐functioning tissue known as a scar. The purpose is to review the repair process here Methods Skin wound healing can be considered as a model organism on which to base on our understanding of cell and molecular biology of the tissue repair. Results Knowledge on the biology of wound healing might help us to unlock latent regenerative pathways and steer the reparative response towards regenerative. Conclusion The identification of regenerative pathways could potentially change our current medical practices on tissue injuries as much as the introduction of antibiotics did for infectious diseases in the twentieth centuryCommercial interest