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Paraneoplastic syndromes
Author(s) -
SZATMARY G,
POLGAR TATJA
Publication year - 2013
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2013.2752.x
Subject(s) - medicine , malignancy , cancer , disease , autoantibody , differential diagnosis , dermatology , incidence (geometry) , pathophysiology , pathology , immunology , antibody , physics , optics
Neuro‐ophthalmologic disorders in the patient with cancer Paraneoplastic syndromes Background: Paraneoplastic syndromes are caused by remote effect of cancer rather than direct invasion. Objective: Review of paraneoplastic neuro‐ophthalmic manifestations, differential diagnosis, diagnostic workup and proposed pathophysiology will be presented. Methods: Literature review along with representative case presentations. Results: Overall incidence of remote effect of cancer is 10‐15 % of all cancers. The number of autoantibodies in association with paraneoplastic syndromes is accumulating. Conclusion: Paraneoplastic syndrome with ocular manifestation may be the first sign of malignancy, and therefore ophthalmologist may play a crucial role in early detection and timely treatment with potential improvement of the disease course.