Premium
The mechanisms of the action of omega‐3s in the retina
Author(s) -
ACAR N
Publication year - 2013
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2013.1613.x
Subject(s) - polyunsaturated fatty acid , retina , oxidative stress , macular degeneration , apoptosis , omega , medicine , biology , bioinformatics , neuroscience , ophthalmology , genetics , endocrinology , biochemistry , fatty acid , physics , quantum mechanics
Age‐related Macular Degeneration (AMD) is the leading cause of visual loss in Western countries after the age of 50y. Based on large‐scale epidemiologic studies, it appears now as evident that omega‐3 polyunsaturated fatty acids (PUFAs) provide benefits in preventing both, early and late stages of AMD. The aim of this paper is to summarize the knowledge about the biological mechanisms by which omega‐3 PUFAs may be protective for the retina. The content of this presentation will range from biochemical data about the occurrence of omega‐3 PUFAs in retinal cell membranes to results from cellular and animal studies showing that omega‐3 PUFAs can influence processes involved in signal transduction, oxidative stress, apoptosis or inflammation.