Premium
Ocular symptoms are not predictive of ocular inflammation in inflammatory bowel disease. A large cross‐sectional survey
Author(s) -
CLOCHé V,
BIGARD MA,
PEYRINBIROULET L,
ANGIOI K
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.t018.x
Subject(s) - medicine , blepharitis , scleritis , metamorphopsia , inflammatory bowel disease , cross sectional study , ulcerative colitis , uveitis , blurred vision , diplopia , prospective cohort study , eyelid , dermatology , ophthalmology , disease , visual acuity , pathology
Abstract Purpose The aims of this study were to assess the predictive value of ocular symptoms for predicting ocular inflammation and the impact of medications on ophthalmologic manifestations in a large prospective cohort of IBD patients. Methods All consecutive IBD patients seen in the Department of Gastroenterology between April 2009 and July 2011 were interviewed for this cross‐sectional study using a pre‐established questionnaire. If the patient had at least one ocular symptom, he systematically underwent an ophthalmologic examination. Results Three hundred and six patients were enrolled in this cross‐sectional study: 169 were women (55.2%), 228 had Crohn’s disease (74.5%), 77 ulcerative colitis (25.2%) and 1 microscopic colitis (0.3%). Ninety‐eight patients (32%) reported at least one ocular symptom: ocular irritation (56.8%), red eye (40.5%), blurred vision (37.8%), ocular pain (31.1%), progressive visual loss (34.4%), myodesopsia (23.3%), eyelid secretion (12.2%), dry eye (9.5%), watering (6.8%), diplopia (5.4%), metamorphopsia (4%), and sudden visual loss (4%). Following ophthalmologic examination (n=79), 41.9% patients had evidence of dry eye (n=31), 14.9% blepharitis (n=11) and 1.4% scleritis (n=1). No uveitis was reported. Methotrexate was associated with dry eye (p=0.03). Conclusion Ocular symptoms are frequent in IBD patients, but are nonspecific and rarely associated with ocular inflammation. Systematic ocular symptoms assessment is of poor value for diagnosing ocular inflammation in clinical practice in IBD patients.