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Repeatability of retinal thickness and volume metrics in neovascular age‐related macular degeneration using the Heidelberg spectralis optical coherence tomography
Author(s) -
DEGLI ESPOSTI S,
COMYN O,
KEANE PA,
TUFAIL A,
PATEL P
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.s028.x
Subject(s) - repeatability , optical coherence tomography , macular degeneration , medicine , ophthalmology , retinal , visual acuity , optometry , mathematics , statistics
Purpose To estimate the intra‐session repeatability of retinal thickness and volume measurements from consecutive raster Heidelberg Spectralis spectral‐domain optical coherence tomography (OCT) scans in patients with neovascular age‐related macular degeneration (nAMD). Methods Retrospective analysis of Spectralis OCT scans taken from 27 patients with a diagnosis of nAMD. Three OCT raster scans were performed by the same observer in the same sitting in consecutive patients attending for nAMD treatment, one of which being taken as a follow‐up after setting a reference point on the baseline scan and one being taken as an independent scan from the baseline one. Retinal thickness and volume measurements were automatically calculated by the onboard software. Bland‐Altman methods of analysis were used to assess repeatability. Results Data from the 27 patients were analyzed with a mean (SD) age of 78 years (7). Mean visual acuity was 20/63 (range 20/200‐20/32) The 95% coefficient of repeatability (CR) was 44 µm and 0.038 mm3 for retinal thickness and volume respectively in the central 1 mm macular subfield for the two independent scans, and it was 32 µm and 0.027 mm3 for the two scans taken with the follow‐up reference. Conclusion We report estimates of the intra‐session repeatability of Spectralis OCT retinal thickness and volume metrics in patients with nAMD. There were comparable repeatability estimates for scans taken with or without setting a reference scan with the onboard software. The results are helpful in distinguishing clinical change from measurement variability in clinical practice.