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The mitotic index in secondary enucleated eyes of previously treated uveal melanoma patients
Author(s) -
BAKALIAN S,
CASSOUX N,
LEVY C,
LUMBROSOLE ROUIC L,
DESJARDINS L
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.s011.x
Subject(s) - melanoma , medicine , mitotic index , uvea , glaucoma , ophthalmology , enucleation , ocular melanoma , surgery , mitosis , cancer research , biology , microbiology and biotechnology
Purpose The aim of this study is to evaluate the difference of mitotic activity in secondary enucleated uveal melanoma cases in two different groups of patients who have been treated previously with conservative therapy. Methods We evaluated two groups of patients. The first group consisted from treated uveal melanoma patients who developed a blind painful eye due to end stage of vascular glaucoma, while the second group consisted from uveal melanoma patients who developed a recurrence of uveal melanoma in the same eye after several years. Moreover, we assessed the relationship of the mitotic activity with the other clinicopathological features of the enucleated eyes of the two groups of uveal melanoma patients. We also, recorded and analysed the data including the age of the patients, the size of the tumor, the location, the cell type, and the treatment modality and correlated with the survival rate. Results Our results showed that there was a significant difference in the mitotic activity between the two groups of patients. The mitotic index was higher in the enucleated eyes of uveal melanoma patients who developed a recurrence at the same eye as opposed to the enucleated eyes of uveal melanoma patients due to other reasons such as vascular glaucoma and blind painful eye. The mitotic activity was almost absent in the majority of enucleated uveal melanoma cases due to vascular glaucoma. Conclusion To the best of our knowledge this is the first report that evaluates the mitotic index in secondary enucleated eyes of uveal melanoma patients.