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Damage of tolerance to glucose (TG) is the predecessor of insular diabetes (ID) and is accompanied by different metabolic changes, which need all‐round research
Author(s) -
GUSHCHA S,
BABOV KD,
YAROSHENKO NA
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.f117.x
Subject(s) - diabetes mellitus , basal (medicine) , chemistry , medicine , endocrinology , lens (geology) , carbohydrate metabolism , biology , paleontology
Purpose To research changes of water‐electrolytic exchange (WEE) in lens and liquid of anterior chamber of eye of rats with latent changes of carbohydrate metabolism. Methods White rats Wistar were taken once subcutaneous introduction of alloxan solution in dose 0,075 g/kg. Results After 14 days in lens and liquid of anterior chamber of eye rats was discovered increase concentration of K+ and decrease concentration of Na+. At the same time content of total tissue water in lens was reduced. Basal level of glucose in blood on an empty stomach was normal. At testing TG was revealed increase of glucose level during 3 hours. Conclusion It was determined in initial stage of ID genesis have occurred changes of water‐electrolytic exchange (WEE). The received results expand concept about pathogenetic mechanisms of ID genesis and may be used in researching of correct influence of natural medical factors (mineral waters, for example).