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Retinal vessel reactivity after cigarette smoking
Author(s) -
CUBBIDGE R,
SUMMERS RJ,
HEITMAR R
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.f113.x
Subject(s) - medicine , provocation test , retinal , blood pressure , cardiology , ophthalmology , diastole , pathology , alternative medicine
Abstract Purpose To evaluate the acute impact of cigarette smoking on retinal vessel reactivity during flicker light provocation. Methods 12 otherwise healthy smokers (mean age 28 (SD 5) years) underwent non‐contact tonometry (Keeler Pulsair, UK), manual shygomanometry and continuous retinal vessel diameter measurements using flicker light provocation (RVA, ImedosSystems, Germany) at baseline and after smoking one cigarette. Smokers had regularly smoked for at least 6 months. For retinal vessel diameter measurements we used a standard protocol with 50 sec baseline diameter recording followed by 3 cycles of 20 sec flicker and 80 sec recovery. Results Immediately after smoking systolic, diastolic blood pressure and heart rate increased significantly (SBP: 112 (13)mmHg to 124 (11)mmHg, p=0.0001; DBP: 69 (10)mmHg to 78 (8)mmHg, p<0.0001; HR: 73 (11)bpm to 83 (10)bpm, p=0.009). However, intra ocular pressure as well as arteriolar and venular diameter were unchanged (IOP: 15 (3)mmHg to 15 (3)mmHg, p=0.633, arteriolar diameter: 126 (15)au to 125 (15)au, p=0.416; venular diameter: 163 (16)au to 167 (15)au, p=0.329). Area under the curve results revealed no effect of acute smoking (arterial: AUC(FL) at baseline 61 (57) and post‐smoking 60 (34), p=0.923; AUC(Cess) at baseline ‐22 (38) and post‐smoking ‐11 (49), p=0,309; venous: AUC(FL) at baseline 54 (56) and post‐smoking 65 (29), p=0.322; AUC(Cess) at baseline 51 (36) and post‐smoking 50 (26), p=0.976). Conclusion The acute effect of a single cigarette did not have an effect on dynamic retinal vessel dilation to flicker light stimulation in cigarette smokers arterioles and veins