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Efficacy of pneumatic trabeculoplasty in patients with primary open angle glaucoma and ocular hypertension in combination with prostaglandin monotherapy
Author(s) -
MARTY A,
BECCAT S,
AMARI E,
NORDMANN JP,
DENIS P
Publication year - 2012
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2012.f045.x
Subject(s) - medicine , ophthalmology , glaucoma , ocular hypertension , intraocular pressure , open angle glaucoma , visual acuity , slit lamp
Purpose To evaluate the safety and efficacy of pneumatic trabeculoplasty (PNT), a non invasive treatment to lower intraocular pressure (IOP), in patients with primary open angle glaucoma or ocular hypertension under prostaglandin monotherapy. Methods 38 patients were enrolled from may 2009 to october 2010 to determine the IOP lowering effects of PNT. All the eyes had been diagnosed primary open angle glaucoma (87%) or ocular hypertension. PNT was performed in one or both eyes at day 0, 7, 90 and 180. Assessments were peformed at day 0,7, 45, 90 and 180 including visual acuity, IOP by goldmann tonometer, slit lamp examination and optic disc evaluation. Safety was adressed at all visits. A 15% reduction of IOP defined responder patients. Results Mean IOP before PNT was 23.21 +/‐ 2,92 mmHg. 57 eyes were treated and analysed. All patients completed 6 months of follow up. After PNT, a statistically significant reduction of IOP occured at all visits: at days 7, 45, 90, 180, IOP was 19,92+/‐5,05, 19,32+/‐5,22, 18,89+/‐5,00, 17,76+/‐4,81 mmHg (p<0,05). The IOP decrease was up to 23,4% at day 180. The rate of responder patients was 54,4% after one week and 76,4% at day 180. After 6 months, 76% patients had IOP reduction more than 15%, 69% more than 20%, 51% more than 25% and 46% more than 30%. Side effects such as conjunctival hyperhaemia, subconjunctival hemorrhage and corneal epithelium disorder occured. No significant complications were observed. Conclusion PNT seems to be a safe technique allowing a significant IOP reduction with prostaglandin monotherapy. It could be helpful especially in patients having troubles in following their local treatment correctly.